I am engaged in a project about biomathematics, see https://www.youtube.com/channel/UCNRmSus_UIUETlWA7bZCZ4A. The professor which is involved on the matter is a professor of PK/PD, a doctor, I am a biomathematician, I have done some publications, see my profile. I am planning in the future to produce some videos regarding the matter, whenever I do it, I will come back to you, however you can follow the project. See the video https://www.youtube.com/watch?v=s6gCvhSh-qc, if you are interested, I can send you the codes. For my publications, I can also send you the codes.
Good luck,
Best regards,
Jorge Pires,
PS. see also http://bookreviewsandcomments.blogspot.it/2014/11/clinical-pharmacokinetics-and.html
See https://www.researchgate.net/publication/280879908_Online_httpgestaoesaudebceunbbrindexphpgestaoesaudeissuecurrent_Accessed_on_May_2015
Currently our product and science training is all delivered in person, however we are currently recording materials that should be available in then next few months; https://www.certara.com/training
Simon
UPDATE 2016: http://www.certarauniversity.com/lms/ is the direct link for online courses and if you are using Phoenix WinNonlin the user forum maybe useful to you too;
There is a discussion group on PK/PD modeling and Bayesian adaptive stochastic control, and methods to optimize all this, on the web site managed by Michael Neely MD. It is www.lapk.org. He runs the USC Laboratory of Applied Pharmacokinetics and Bioinformatics, which is at Children's Hospital of Los Angeles. There is also a lot of material available on the subject, software for population PK/PD modeling, and also software for clinical use. All the activities of this lab are oriented toward clinical use and the development of dosage regimens which hit desired target therapeutic goals with maximum precision.
Maximum precision cannot be achieved using models in which the shape of the population parameter distributions is assumed, such as normal, lognormal, bimodal, etc.This is why this lab uses nonparametric models which estimate the entire parameter distributions without having to make any such constraining assumptions about their shape. This permits use of multiple model dosage design, to develop dosage regimens which hit targets with maximal precision. This is something parametric models cannot do, nor do you even become aware of the issue of precision using parametric models as in NONMEM, for example.
Parametric models develop dosage regimens based only on the estimated central tendencies of the model parameter distributions.
In contrast, nonparametric models permit development of maximally precise dosage regimens, using the entire parameter distributions.
For those who are interested in maximally precise dosage (why else make models, except to use them eventually for patient care?), info can be obtained at www.lapk.org. Much material equivalent to course material can be found there as well.
we have recently launched this site and some courses are focussed around Phoenix WinNonlin whilst others are platform independent theory-based sessions.
More online courses are to be added shortly and of course we still have our public courses around the world as well as the option for a customised course to be delivered at your own site.
The book edited by myself and Michael Neely MD is the equivalent of a course in population PK/PD modeling, maximally precise dosage for patient care, and four different Bayesian methods of analysis, including modeling drug behavior in acutely ill, unstable patients, in which the model parameters can change, if needed, as new data becomes available. More info is available at Amazon, books, and entering "individualized Drug Therapy for Patients". It provides a course in PK/PD modeling and its practical applications to optimally precise patient care, with application to infectious diseases, transplants, cancer, epilepsy, digoxin, the elderly, and many other topics..
UPDATE 2018: Certara University now also offers a series of on-demand courses on Population PK/PD modeling. There are 3 levels, beginner, intermediate, and advanced. The courses contain theory lectures and exercises performed using Phoenix NLME. The beginner and advanced on-demand courses are available today and the intermediate course is to be released on March 2018. These courses are also taught regularly in a classroom setting.
You can find additional information at https://www.certara.com/training/?ap%5B0%5D=TR
You can also read. There is a book on pop modeling, with more and better methods described than NLME or NONMEM. You can go to Amazon, books, and enter "Individualized Drug Therapy" The book, which contains material on both parametric and nonparametric population PK/PD modeling and its uses, without which such modeling is moot. Only nonparametric models permit development of maximally precise dosage regimens for patients. This is something about which the pharmaceutical industry should give much more thought.
Thanks Roger. What's the title of the book?. I also tried to look at the website you suggested, unfortunately the Pmetrics R package is not available for R vesion 3.4.2. I also wanted to know whether Bestdose software is free.
The title of the book is "Individualized Drug Therapy for Patients" You can go to Amazon (the cheapest I know), books, and enter Individualized Drug Therapy, and it should come up.
Thanks so much, Andres. Yes, people are starting to use it as a text for courses in PK and Individualized Drug Therapy. How are all of you and your super dogs! Our sweet little Diamond died last Tuesday with bad DIC, in my arms as they worked on her. Here is a Powerpoint file ending with me scratching her ear and her paw on my hand. She was so sweet, and I miss her so! She taught me all about love, and now I can pass her gift to me on to others!
You can try at Metrum Institute, they have several courses on PK/PD: MI210: Essentials of Population PK-PD Modeling and Simulation - Metrum Research Group (metrumrg.com)