What is the role of thiamine in the management of anti-retroviral drug induced peripheral neuropathy and lactic acidosis?

More Mwila Mulubwa's questions See All

How do you perform parameter optimization in PK-Sim?

Apart from the available sources from http://www.open-systems-pharmacology.org/ on PBPK model building workflow, how can you optimize parameters in a case were simulated data is different from...

12 March 2020 3,772 2 View

Why should the volume of distribution of a metabolite be assumed to be same as the parent drug?

When modelling parent and metabolite pharmacokinetics it's assumed that the volume of distribution of the metabolite is same as that of the parent drug. Why this assumption?

24 July 2017 571 4 View

Is there an online course in PK/PD Modelling?

Does anyone know where I access an online course in PK/PD modeling?

26 December 2015 3,841 21 View

Which model can I use to quantify antibiotic regimen synergy in-vivo?

Which PK-PD model can I use in order to quantify the synergy of a combination of 4 antibiotics?

09 June 2015 1,712 2 View

Do systemic corticosteriods have a role in the management of immune reconstitution inflammatory syndrome in AIDS?

Should prednisolone be used in the management of immune reconstitution inflammatory syndrome in patients with HIV/AIDS?

24 December 2014 6,344 9 View

What is the mechanism of efavirenz induced depression or psychotic symptoms?

Efavirenz is known to cause CNS effects. Symptoms resolve within 3 to 6 months but in some patients may persist until efavirenz is substituted for nevirapine.

15 January 2014 1,026 4 View

What accounts for a peak height difference between internal standard and analyte at same concentration?

What will cause the internal standard to have a higher peak height than the compound of interest If the compound of interest and internal standard are at the same concentration? The instrument has...

04 September 2013 9,161 4 View

What should determine the volume of the mobile phase needed to reconstitute the residue?

Is there a standard volume that you need to use to reconstitute the residue after extraction of a drug from plasma? Or what should determine the volume of the mobile phase needed to reconstitute...

22 August 2013 3,681 3 View

What is the minimum dose range of morphine that can cause respiratory depression in non cancer pain management?

Respiratory depression

17 August 2013 1,695 3 View

Request Python code?

Request Python code from this article : Gender equity of authorship in pulmonary medicine over the past decade. THANKS!

08 August 2024 6,242 2 View

Why does everyone use vs code?

Visual Studio Code (VS Code) has become a popular choice among developers for several reasons: 1. **Free and Open Source**: VS Code is free to use and open source, making it accessible to...

07 August 2024 7,013 4 View

Is an invitation to join the editorial board of Clinical Cardiology Updates a scam?

I received an e-mail invitation to join the editorial board of Clinical Cardiology Updates. While I have published a few articles related to cardiovascular disease, there are lots of colleagues...

06 August 2024 8,981 8 View

How can i do multivariate Time Series forecast using MLP, ANFIS and LSTM?

I need the python code to forecast what crop production will be in the next decade considering climate and crop production variables as seen in the attached.csv file.

05 August 2024 2,977 3 View

How can i study the carboplatin using spectroscopic technique, viz Raman and FTIR spectroscopy?

I'm working on carboplatin which i bought from local pharmacy. It is a Carboplatin injection IP 150mg/15ml which is sterile aqueous solution for intravenous use. Unfortunately, I cannot able to...

04 August 2024 454 3 View

Posthoc test lettering in JAMOVI?

Does anyone know of a module for the JAMOVI software that is capable of generating mean separations using the classic letters based on post hoc results (e.g., Tukey test)? If, as I believe, such...

31 July 2024 3,333 4 View

Can anyone please provide me the full text article of this clinical Trial?

Roflumilast Cream Improves Signs and Symptoms of Plaque Psor...

29 July 2024 5,250 0 View

What is your major research area?

My major research area is clinical research and basic research of thyroid and parathyroid.

26 July 2024 3,639 14 View

Is the zero-zero component of the metric tensor equal to 1 for accelerating reference frames?

Consider the case of negligible gravity but there is an accelerating reference frame. Its origin traces out a trajectory, or world line, seen in some inertial reference frame. The Lorentz metric...

24 July 2024 1,608 15 View

How can i solve the code problem in Sentaurus TCAD?

Currently, I have created a gate-all-around process using sentaurus tcad and I am trying to measure the noise using the cmos noise code. However, an error occurred during the simulation. The error...

24 July 2024 6,352 0 View

Adejuwon Adeneye

Thiamine has been reported to be depleted rapidly by ARV therapy causing peripheral neuropathy and lactic acidosis. The essence of thiamine supplementation in the course of ARV therapy is to replenish its reserve and prevent development of these untoward effects

Sultan Salah

i agree with Adejuwon.