Efavirenz is known to cause CNS effects. Symptoms resolve within 3 to 6 months but in some patients may persist until efavirenz is substituted for nevirapine.
From Clinical Pharmacology: Commonly reported psychiatric symptoms during efavirenz therapy include depression (
Interesting question. It goes hand in hand with the fact that Interferon alpha given treat people with hepatitis C makes around 40% of them develop a full blown major depressive episode. These are people who never had psychiatric problems in their lives. We believe it is a clinical model for inflammation-induced depressive symptoms a theory we work a lot in my lab.
Despite little evidences that can mention mechanism of action of efavirenz and CNS toxicity, here is an evidence
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