I am working on the Pluronic F127, well known for its temperature sensitivity. I try to make nanomicelles using this copolymers by placing myself above the CMC and CMT. I would then like to stimulate the release of my encapsulated assets after the application of a heat source. But after being up to 95 ° C, no change seems to be happening - I still have "intact" nanomicelles. In the literature, the LCST of Pluronic is close to 32 ° C. Is there a link between CMC / CMT and LCST?
Dear Louise,
The LCST phenomenon in pluronic manifests as this transition from a majority unimer state to a micellar state at the CMT. Our experience is that this occurs at ca 20-25 C. You could test the CMT using a technique such as Dynamic Light Scattering. It may be affected by solvent choice or the presence of a drug.
- Badges
- Science topic
- Similar topics
- Biological Science
- Biochemistry
- Biomolecules
- Peptides