Is Reductive alkylation (schiff's base) of N terminus-NH2 group of protein and aldehyde( -OH) group possible at PH 7-8? or only acidic PH 4-6?

09 July 2015 1 7K Report

Atish Mehetre

Acidic condition is more favorable generally we use 3 to 4 drops of glacial acetic acid for the preparation schiff base

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