This paper describes in part what is going on with Influenza A:
Article Influenza A: Understanding the Viral Life Cycle
and says, "The influenza viral genome is made up of negative sense strands of RNA. In order for the genome to be transcribed, it first must be converted into a positive sense RNA to serve as a template for the production of viral RNAs.
Replication of the genome does not require a primer; instead, the viral RNA dependent RNA polymerase (RdRp) initiates RNA synthesis internally on viral RNA. This is possible, as the extreme 5’ and 3’ ends of the genome exhibit partial inverse complementarity and, hence, are able to base pair with one another to form various corkscrew configurations. It appears that a great number of di-nucleotide base pairs form, although the full mechanism of viral genome replication is still yet to be understood"
Does this mean that the RdRp is inserted in the nucleus along with the viral RNA, or derived from it inside the nucleus? Does the RdRp serve as its own 'factory', separate from the host's own transcription mechanism? Or does the RdRp replicate the viral RNA inside the viral capsule which is still out in the cytoplasm, and only viral RNA gets inserted into the nucleus?
1. Yes, RdRp is inserted into the nucleus alongside the vRNA.
2. RdRp serves as its own factory but not completely unassociated ; cap snaching from host pre mRNA is example
3. Viral capsule remains in the nucleus . Only viral genome enters and replicate inside the nucleus.
So Influenza A kills or damages the host by stealing its nucleic acid building blocks and using them in its own factory set up in the host's nucleus, to produce more RNA from its own RNA template, and then, when the viral RNA exits from the nucleus, somehow the virus manages to wrap it in a bit of the host's membranes, altered to create a new viral capsule? I think you meant to say viral capsules remains in the cytoplasm. If you meant viral capsules stay in the nucleus, what remains in the cytoplasm to package the newly produced RNA?
Packaging signals are present in each segment of viral RNA that initiate packaging.
You can read this article ⬇
Hideo Goto, Yukiko Muramoto, Takeshi Noda, Yoshihiro Kawaoka
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