Hello Serdar Menekşe

This area has many doubts. Its effectiveness and efficiency are hard to measure. There is a significant amount of variability in effectiveness because it is a patient-derived product. The unknown factor offers some specific concern. What may work for one patient, not necessary it should have the same effect on another patient due to the composition of platelets.

So, in a way, what you have mentioned about platelets is right.

What is actually needed is to perform more controlled trials. There should be a well defined standardized protocol in place and comparing its effect with other therapeutic techniques.

You may find more information on this topic in the article attached below.

https://www.drprpusa.com/blog/platelet-rich-plasma-injections-more-than-just-placebo.html

Best.

you are absolutely right, as it is a patient-dependent treatment method, the effect may vary from patient to patient, thank you very much for your answer.

Dear Serdar Menekşe

PRP (Platelet Rich Plasma) is a treatment that has gained attention in various medical specialties, including orthopedics, wound healing, and dermatology [1,2]. PRP is derived from the patient's own blood and contains platelets that release growth factors to promote healing and regeneration [3]. However, the effectiveness of PRP is still a topic of debate.

Here are some key points to consider:

1. Mechanism of Action: PRP works by delivering growth factors to the site of injury or treatment, stimulating tissue repair and regeneration [3].

2. Variability in Preparation: There is a lack of standardization in PRP preparation methods, including differences in harvesting, preparation, and activation techniques, which may affect its therapeutic effect [2,3]

3. Placebo Effect: Placebo can have an impact on subjective and even objective results in clinical trials. In the case of PRP, the placebo effect has been observed in studies evaluating the symptoms of chronic prostatitis [4].

PRP shows promise in various medical applications, its effectiveness and the role of placebo effects need further investigation. Standardization of PRP preparation methods is also necessary to maximize its therapeutic potential [2-4].

PRP (Platelet-Rich Plasma) is not a placebo. PRP is an autologous biologic product used for tissue repair due to its regenerative properties. It contains a higher concentration of platelets and extraplatelet biomolecules, which enhance its regenerative performance [5].

I have found and added several literature sources that cite several studies on the effects of PRP, with different results regarding its effectiveness and placebo effect:

1. A study found that placebo contents were described in only 19.5% of placebo-controlled randomized clinical trials (RCTs) published in high-impact medical journals [6].

2. Another abstract discusses the challenges of utilizing placebo effects in medicine and proposes a framework to reintegrate non-drug variables into the biomedical toolbox for improved clinical care [7].

3. A study on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) found that the placebo effect had a significant influence on symptom improvement [4].

I am attaching links to the literature I have reviewed:

1. Chapter The Growing Role for Platelet Rich Plasma in Cosmetic Dermatology

2. Article Technical Procedures for Preparation and Administration of P...

3. Chapter Platelet-Rich Plasma Therapy: An Overview

4. Article A systematic review and meta‐analysis of placebo effect in c...

5. Article New Formulation of Platelet-Rich Plasma Enriched in Platelet...

6. Article Definition and rationale for placebo composition: Cross-sect...

7. Article Harnessing placebo: Lessons from psychedelic science

I hope you find this information useful.

Best regards