Curative resection in signet ring cancer is difficult. Even when the primary tumor appears to be localized without nodal or peritoneal spread, tumors often prove to be more advanced than originally thought on the basis of radiologic techniques or intraluminal ultrasound. More extensive surgery than intersphincteric resection therefore appears to be advisable.
I woluld not perform intersphincteric resection in signet-ring or poorly differentiated cancer since there is too high a risk of local recurrence. What is more, the preoperative radiation or chemoradiation should be applied to improve local control after curative surgery.
our experience is similar to what was mentioned by Dr Piotr,Local recurrence is high with ISR,and these pts in India are younger.However chemo rad followed by ISR with informed consent or APR is our practice.