I have one drug candidate in diastereomeric mixture. Is it possible to identify the number of isomers in diastereomeric mixture by using the second derivative calculations and Gaussian curve fitting analysis of DTG (Differential Thermogravimetric analysis) curve by using OriginPro 8 software?
Dear Sameer....Unfortunately, the TG is not the choice for such identification of isomers. We have studied a large number of organic compounds (preferably solid) by TG and all isomers show the same behavior. Isomers are almost identical in the thermal decomposition profiles. However, if the isomers differ with their melting or even boiling points, there may be some degree of identification and discrimination between them by the DSC technique following their melting or boiling peaks.
Dear Sameer....Unfortunately, the TG is not the choice for such identification of isomers. We have studied a large number of organic compounds (preferably solid) by TG and all isomers show the same behavior. Isomers are almost identical in the thermal decomposition profiles. However, if the isomers differ with their melting or even boiling points, there may be some degree of identification and discrimination between them by the DSC technique following their melting or boiling peaks.
I agree with Mahmood. DSC is the technique that can help you partially solve your problem of isomer differentiation.
I agree with Professor Mahmood M. Barbooti,
I think DTA and DSC may help you with that. However, if you have NMR facility it will be more helpful.
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