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Questions related from Sameer Karpe
I optimized the structure of protein through energy minimization in a spherical water box with 0.15 M NaCl to maintain the charge at neutral using the CHARMM 27 force field, Langevin force field...
08 August 2018 7,141 5 View
Recently I synthesized the 3-substituted 3-amino oxindole starting from ketimines derived from isatin. After close examination, I come to know that the final product is in the racemic form. I want...
05 May 2018 7,952 3 View
Recently, I tried to synthesize one organic intermediate having carbon-carbon triple bond. After recording its proton NMR, I came to know that it has a small amount of allene form also. My...
12 December 2017 7,247 3 View
I have one drug candidate in diastereomeric mixture. Is it possible to identify the number of isomers in diastereomeric mixture by using the second derivative calculations and Gaussian curve...
12 December 2017 880 4 View
The PETRA is a software package comprising various empirical methods for the calculation of physicochemical properties of organic molecules. It helps to quantify the chemical effects such as heats...
10 October 2017 9,331 1 View
I am studying the effect of solvatochromic dyes on the micellization of mixed catanionic surfactant mixtures in a various medium. I am new in this field; kindly provide me step by step protocol...
08 August 2017 3,474 4 View
In organic chemistry we use molecular sieves (4A Beads) for drying of organic solvents. I want to know how to confirm the threshold limit beyond which the molecular sieves (4A Beads) cannot be...
05 May 2017 7,194 6 View
I have recently analysed the organic molecules, using Shimadzu LCMS 2010A (Japan) by positive electron spray ionization mode. This instrument exports files in .lcd format. I tried mMass and...
05 May 2017 3,293 3 View
I am synthesising N-(Benzyloxycarbonyl)-L-serine benzyl ester starting from N-(benzyloxycarbonyl)-L-serine by using benzyl bromide in aq. NaOH and Acetonitrile under reflux...
02 February 2017 242 13 View
I recorded the TGA and DSC of few active pharmaceutical ingredient (API). Out of 14 samples, the ten samples contains the enantiomeric racemate; while four samples are in diastereomeric racemate....
01 January 2017 7,288 2 View
Please tell me how to calculate critical micelle concentration of various aqueous solutions + surfactants by 1H NMR?
08 August 2016 6,710 7 View
Recently I carried out alkyne formation reaction. However, I have a doubt whether only alkyne is the product or allene is also get formed? I just took simple 1H NMR (500 MHz). It shows me a...
06 June 2016 873 7 View
what is the exact role of NH4Cl (ammonium chloride) in aqueous barbier type reactions?
10 October 2015 1,799 3 View
Could anyone provide a details on separating allene from alkynes in the mixture of allene and alkyne?
05 May 2015 1,418 3 View
