In mitosis, colchicine acts as an inhibitor, where it arrests the spindle formation during metaphase so that they don't get separated during anaphase. So is it a chromosomal aberration or is it normal?
Hi Ankita,
Applying colchicine on mitotic cells leads to polyploidization.
Polyploidization can occur naturally, as unreduced gametes for example, but in your case, it is a drug induced polyploidization, and can therefore be considered as an abnormality.
Cheers
Oliv
Thank You Olivier Catrice Sir for the response. As per your answer polyploidization is a result of application of colchicine. What I want to know here is that in such a case where from does it get secreted in the body?
Colchicine is a plant toxin from Colchicum (Liliaceae), it is not produced in animal body.
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