I am looking for papers describing neurotransmitters changes and possible therapeutic implication for the treatment of symptoms of dementia such as agitation, aggression, apathy, psychosis, depression and others.
Dear Tomasz,
You may be familiar with these papers:
Agitation in Dementia: Relation to Core Cerebrospinal Fluid Biomarker Levels. Victor Bloniecki, Dag Aarsland, Jeffrey Cummings, Kaj Blennow, Yvonne Freund-Levi
Dement Geriatr Cogn Dis Extra. 2014 May-Aug; 4(2): 335–343.
A review of neuroimaging findings of apathy in Alzheimer’s Disease
Christos Theleritis, Antonios Politis, Kostas Siarkos, Costantine G Lyketsos
Int Psychogeriatr. Author manuscript; available in PMC 2015 February 1.Published in final edited form as: Int Psychogeriatr. 2014 February; 26(2): 195–207.
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
Scott J. Webster, Adam D. Bachstetter, Peter T. Nelson, Frederick A. Schmitt, Linda J. Van Eldik. Front Genet. 2014; 5: 88.
Chronic Neuroinflammation in Alzheimer's Disease: New Perspectives on Animal Models and Promising Candidate Drugs
Christopher Millington, Sandra Sonego, Niloo Karunaweera, Alejandra Rangel, Janice R. Aldrich-Wright, Iain L. Campbell, Erika Gyengesi, Gerald Münch
Biomed Res Int. 2014;
Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy
Shuko Takeda, Naoyuki Sato, Ryuichi Morishita
Front Aging Neurosci. 2014; 6: 171.
Frontotemporal lobar degeneration: current perspectives
Lina Riedl, Ian R Mackenzie, Hans Förstl, Alexander Kurz, Janine Diehl-Schmid
Neuropsychiatr Dis Treat. 2014; 10: 297–310.
Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer’s disease: study protocol of a randomized controlled trial (The FIT-AD trial)
Fang Yu, Ulf G Bronas, Suma Konety, Nathaniel W Nelson, Maurice Dysken, Clifford Jack, Jr, Jean F Wyman, David Vock, Glenn Smith
Trials. 2014; 15(1): 394.
The Effects of an Uninterrupted Switch from Donepezil to Galantamine without Dose Titration on Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease
Shoichi Sasaki, Yoshiharu Horie
Dement Geriatr Cogn Dis Extra. 2014 May-Aug; 4(2): 131–139
Serum homocysteine levels are correlated with behavioral and psychological symptoms of Alzheimer’s disease
Hyun Kim, Kang Joon Lee
Neuropsychiatr Dis Treat. 2014; 10: 1887–1896.
Dear Beatrice, Thanks a lot for these references. Unfortunately, this is not what I am looking for. I am interested more in neurotransmission and possible relationships to treatment options.
Aha, I misunderstood you but I saw your papers too from 2012!
Dear Tomasz Sobow
Although below mentioned article is a review article but going through the mentioned neurotransmitter related pathophysiology you might get an idea about the research paper mentioned in the references.
Clinical Medicine Research2015; 4(2-1): 8-14 Published online February 6, 2015 (http://www.sciencepublishinggroup.com/j/cmr) doi: 10.11648/j.cmr.s.2015040201.12 ISSN: 2326-9049 (Print); ISSN: 2326-9057 (Online)Behavioral and psychological symptoms in dementia and caregiver burden Arshad Yahya, Mina Chandra*, Kuljeet Singh Anand, Jyoti Garg
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