Does targeting soluble protofibrils of amyloid beta plaques produce any effect on the insoluble sections of the plaques?

Based on the results of phase 2 trial of experimental anti-amyloid drug BAN2401, I was wondering if the positive effect of this antibody on dissolving the fibrils and reducing the cumulative...

06 July 2018 6,880 0 View

What is the outcome of combining antihistamine medications with antipsychotics and antidepressants?

What are the potential interactions between these three classes of drugs and how is their metabolism in an individual affected?

04 May 2018 3,493 4 View

What accounts for the differences between plasma and brain levels of amyloid plaques in Alzheimer's disease patients?

Is there a possible correlational relationship between the two?

03 April 2018 1,974 3 View

How is the effect of dopamine on the cerebrovascular system of the brain? Is it vasodilatory or vasoconstricting?

It seems that dopamine effect on cardiac vessels is mixed and varies with dose? Does this variation also apply similarly to cerebral vessels? Any application of this neurotransmitter in ischemic...

01 February 2018 6,180 2 View

How is the interaction between the brain and heart's magnetic fields like?

Is it possible to measure the brain and heart's magnetic fields in combination so as to study their influence on each other's strength?

01 February 2018 9,055 4 View

For cases of frequent nosebleeds that are hard to prevent, can promoting faster blood-clotting help lessen long-term blood loss?

Is it wise to administer drugs which promote blood clot when nosebleeds occur more than five times in a month due to a past surgical procedure? Is there any topical application type available so...

31 December 2017 7,979 1 View

Can environment factor(s) play a part in affecting intracranial hypertension?

For example, can the temperature of external surrounding affect the state of cerebrospinal fluid in the brain which in turn leads to intracranial hypertension?

11 December 2017 2,978 3 View

Is there any way to image cerebral vasoconstriction?

Is it possible using angiography, fMRI or PET scan?

11 December 2017 8,492 4 View

What are the causes of psychogenic nonepileptic seizures?

Is stress a major contributor?

11 December 2017 3,981 4 View

Can blood pressure increase occur independently of high cortisol level?

We know that cortisol induces vasoconstriction which leads to increase in blood pressure. But can this relationship be bidirectional such that elevated blood pressure happens prior to cortisol...

10 November 2017 1,334 8 View

Is there a powerful system for the security of the systems distributed on IoT systems?

Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

Which is a lucid standard comprehensive book to guide on psychological scale construction and its standardization?

02 March 2021 7,082 3 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

LOAD DISPLACEMENT CURVES Stiffness increasing in ANSYS non linear analysis. HOW CAN I CORRECT IT?

Hi. I am doing non linear FE analysis using a new material beam under flexural 2 point loading using ANSYS. I have defined a bilinear material model. The solution has converged. In results I am...

01 March 2021 9,911 3 View

How to choose ANN number of hidden layers and nodes?

Hello, Could you please share any interesting research explaining how to choose the number of hidden layers and nodes per layer in case of regression problems using ANN? Thank you, any help would...

01 March 2021 6,200 3 View

PUC19 as a transfer plasmid for lentiviral delivery?

Hello, Is it possible to use pUC19 as a transfer vector to be packed in using the second generation viral particles packaging system( pMD2.G; psPAX2 plasmids)? As far as I understand it there is...

28 February 2021 4,868 2 View

For modelling epoxy-based matrices (in composites), which model in ABAQUS is the most suitable, Concrete damaged plasticity or Drucker-Prager model?

I am working on developing a micromechanical FE model for predicting kink-band formation in UD composites. To model matrix plasticity, which model, out of Concrete Damaged Plasticity and...

28 February 2021 5,415 1 View

How could I take into consideration the weights of observation in a system of seemingly unrelated regressions (SUR) in rstudio?

I build a model of 4 regression equations (probit and OLS) in R studio. I need to take the weights of observations into consideration. While it is simple to do so for every regression equation,...

27 February 2021 1,233 1 View

Can random sampling have inclusion criteria?

As random sampling means that everyone in the population have an equal chance to be chosen, can it have inclusion criteria? My research participants have been chosen based on the inclusion...

26 February 2021 6,905 10 View