We know that cortisol induces vasoconstriction which leads to increase in blood pressure. But can this relationship be bidirectional such that elevated blood pressure happens prior to cortisol release? Or can blood pressure be increased independent of the cortisol pathway? There seems to be other physiological processes which can contribute to blood pressure increase but can they subsequently involve additional cortisol release?
Of course, the pressure rises regardless of the level of cholesterol. For example, the young. Or in patients who have normal cholesterol. If to speak from the standpoint of vessel stiffness, then this is a long process. And the very increase in blood pressure can lead to an increase in the rigidity of blood vessels and impair the spread of the pulse wave. But often patients have both increased pressure and high cholesterol ... There are many options. But the answer to your question is that these processes are not connected.
Hi Kong.. Cortisol Is very important substrate for maintaining blood pressure. Cortisol defficency can cause hypotension. On the other hand increase in Cortisol level in cushing syndrome is often associated with hypertension. How increase Cortisol produces hypertension not well known. Sodium and water retention is an important factor. Data does not support that sympathetic nervous system activation is an important factor. There are some suggestions that increase Cortisol may impair nitric oxide pathway and may have some role in producing hypertension. However all cases of hypertension are not due to increase Cortisol. Increased sympathetic activities and activation of renin Angiotensin system is also very important for development of hypertension. Hypertension may be due to activation of sympathetic, renin Angiotensin system or Cortisol pathway.cortisol pathway is important but it have not always have significant role hypertension..
Hypertension and Cortisol
Please let me know if these references/sites are helpful to you:
1. Cushing, Cortisol, and Cardiovascular Disease | HypertensionWeb ·
hyper.ahajournals.org/content/36/5/912
The recognition that glucocorticoid excess produces hypertension led to examination of the role of cortisol in essential hypertension, ... Cushing, Cortisol, and ...
2. CORTISOL AND HYPERTENSION - Kelly - 1998 - Clinical and ...Web ·
onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.1998.tb02301.x/...
CORTISOL AND HYPERTENSION. ... Cortisol-induced hypertension is accompanied by a significant sodium retention and volume expansion. ... Standard PDF (657.5 KB ...
Dennis
Dennis Mazur
Thanks, Dennis. I will look up the articles when I have the time, but it already seems like they should be very useful in providing the answers to my question!
Now, looking at the abstract of the second article, it seems like cortisol, hypertension and sodium retention are somewhat involved though not very significant. I was wondering if the level of cortisone in our body has any influence on the release of vasopressin(anti-diuretic hormone). Based on a clinical case I once casually came across, low cortisone seems to trigger increased urinary output which could be a result of concurrent decrease in release of vasopressin. So could there be a positive correlational relationship between cortisone and vasopressin which indirectly bring about blood pressure changes?
Hi Kong,, three are some suggestions that vasopresion can increase the Cortisol release from adrenal glands in human.. Thanks
Hi Kong.. In animals like dogs there are some suggestions that Cortisol inhibits vasopression release. But in human vasopression has some role in releasing and synthesis of Cortisol in adrenal glands. Vasopresion containing cells have been found in adrenal cortex. Vasopresion probably acts through v1receptor in adrenal glands... Thanks
A confounding question: Can blood pressure be taken without stimulating cortisol release?
Dennis
Dennis Mazur
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