If anyone have idea about how to soluble Polydopamine nanoparticles?

More Vijay Mokalla's questions See All

What pH condition required to coat APTES on silica coated Fe3O4?

It's a hydrolysis reaction, which may produce by either acid or base-catalyzed reaction. so can anybody help me with this, which condition is suitable for this reaction?

26 February 2021 1,760 8 View

What condition required for coating of Fe3O4@SiO2 by using APTES?

I tried coating Fe3O4@ SiO2 by using APTES in 5% water-ethanol but it is not coated. Kindly suggest a solution for it. Thanks

24 February 2021 5,992 4 View

How to Control Whiteflies in coconut leaves?

24 February 2021 1,005 1 View

Is it possible to design digital all pass filter for specific frequency range of the system?

I would like to know, Is it possible to design digital all pass filter for specific frequency range of the system to alter the phase of the system in that specific range of frequency? If yes how...

26 November 2020 1,402 5 View

In some CP patch design the polarization changes for LHCP to RHCP, What should be the possible reasons?

I have designed a dual print dual cp antenna, identical patch on both side of the substrate (placed side by side), on analysis, it is found it is showing LHCP in one band and RHCP in another band....

04 August 2020 5,136 3 View

In dual band antenna why the gain in upper band decreases?

In some printed antenna designs, generally, the gain in the upper band is larger than the lower band. However, in some cases (in my design having printed circle on both side of the substrate like...

03 August 2020 5,802 5 View

How to cap the maximum amount of reinforcement addition to make a polymer to be thermally conductive?

Addition of reinforcement with very high thermal conductivity (ex. graphene) would enhance the thermal conductive value of the developed polymer composites. How would one cap the maximum weight...

21 June 2020 9,303 11 View

We are facing rotten problem in kesar mango near mouth of it. What may be reason for that?

We are doing natural farming of kesar mango. This year we are facing rotten problem in mango near mouth of it. Last year it seems good. For this reason we are facing problem in selling if it....

02 June 2020 5,277 7 View

In COVID-19 modeling estimates for India by CDDEP, Johns Hopkins, and Princeton, what decideds peaking and decay?

COVID-19 modeling estimates for India have been presented by a team of researchers affiliated with CDDEP, Johns Hopkins, and Princeton. The results described in...

28 March 2020 1,623 2 View

Up to what temperatures can nCovid-19, novel corona virus survive?

The question does not require much explanation. Interested to know if there is some study on overall pattern of temperature range of permanent inactivity of various viruses and bacteria of all...

10 March 2020 8,749 44 View

I need to image mesoporous silica nanoparticles that are in ~100 nm size and do high resolution TEM to look at mesopores. what grids should I use?

Need to image mesoporous silica nanoparticles using the TEM. Also, need high resolution TEM images to see the mesoporous structure. Kindly suggest what kind of grids to use. Thanks, Shatadru

02 March 2021 1,787 2 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Can chitosan alone can act as a reducing agent for Cu(0) nanoparticle sythesis?

[Synthesizing Cu nanoparticles without using chemical reductants]

01 March 2021 8,359 1 View

What are the new 2D nanomaterials were used for Silver nanoparticles stabilization?

In the stabilization of AgNPs are vital in current research interest. However, some of the 2D nano-materials like graphene oxide, MoS2, etc... previously used to stabilize it. But still they shown...

01 March 2021 2,207 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How to check the uv-vis absorption of nanoparticle by surface plasmon resonance?

I try to check the uv-vis absorption of Indium nanoparticle. Now I am measuring in solution, can I measure it in the form of a film?

01 March 2021 930 3 View

Distribution of particles in metal matrix?

How would define the "good" and "poor" distribution of particles within the matrix. Is there a quantitative solution to assess the distribution of the particles, which then having denotation of...

28 February 2021 7,397 8 View

How can I calculate the rdf of water molecules around 'Na' ions that are closest(adsorbed) to the nanoparticle(solute)?

Hi, I want to calculate the radial distribution function for water molecules around the Na+ ions adsorbed on the surface of a spherical nanoparticle using the gromacs trajectory dynamically? For...

28 February 2021 5,650 1 View

LEDs on Vis Light photo degradation of MB water sol via N doped TiO2 in a mini flume?

Good day to all, I have no experience with light emitting diodes. I am building a glass mini flume to demonstrate the photo degradation of Methylene Blue in water running over self cleaning...

26 February 2021 4,026 5 View

Can anyone share his experience regards Smoothing in origin?

I am working on TiO2 composite material and the results of XRD have a lot of small/junk peaks and while I apply a smooth filter in Origin then the other characteristics peaks disappear so anyone...

26 February 2021 8,183 3 View

Muhammad Kashif

Dear Dr Vijay

Polydopamine nanoparticles (PDA NPs) are a type of versatile and popular nanomaterial known for their adhesive and functionalization properties. However, if you're looking to dissolve or solubilize them, it's important to note that polydopamine is generally not very soluble in common organic solvents. Polydopamine particles tend to aggregate, making them difficult to disperse in solvents.

Here are some strategies you could consider to enhance the solubility of polydopamine nanoparticles:

Buffered Aqueous Solutions: Polydopamine nanoparticles are often more soluble in buffered aqueous solutions, especially under slightly alkaline conditions. You can try using buffers like Tris-HCl, phosphate-buffered saline (PBS), or other mild buffers to help disperse the nanoparticles.

Surfactants: Surfactants can help stabilize and disperse nanoparticles in solvents. Nonionic surfactants like Tween 20 or Tween 80 are commonly used for this purpose. However, finding the right surfactant and concentration might require some experimentation.

Sonication: Ultrasonication is a technique that applies high-frequency sound waves to break up aggregates and promote dispersion of nanoparticles in a solution. Be cautious not to use excessive power, as this might cause damage to the nanoparticles.

Organic Solvents: While polydopamine is not highly soluble in common organic solvents, you might try using some polar organic solvents like dimethyl sulfoxide (DMSO) or N,N-dimethylformamide (DMF). However, the solubility might still be limited.

Functionalization: If your application allows, you can modify the surface of polydopamine nanoparticles by attaching functional groups that are more soluble in your desired solvent. For example, adding hydrophilic functional groups might improve solubility in water-based solvents.

pH Adjustment: The solubility of polydopamine can be influenced by the pH of the solution. Experimenting with pH adjustments could help you find a condition where the nanoparticles are more soluble.

Polymer Coating: You can try encapsulating polydopamine nanoparticles with a thin layer of a polymer that is soluble in your desired solvent. This can help improve dispersion and stability.

Titus Sobisch

if you dissolve the particles it means they get extinct. https://drive.google.com/file/d/1z7nM0U8vOJ2uKuoDGIZyf07WnWK8xOUo/view?usp=drive_link

Pan Ni

I agree with Titus, if you dissolve the particles, the particles get extinct, what left may not be polydopamine due to its insolubility in water. It may theoretically become dopamine or byproducts came from degradation. If your purpose is get monomer like dopamine, why not directly dissolve dopamine in water or ethanol to make a solution? Hope it helps.

Zohreh Khoshraftar

Hi. 1-Polydopamine nanoparticles can be soluble in certain organic solvents, such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), or ethanol. 2-You can modify the surface of Polydopamine nanoparticles with different functional groups that impart solubility. 3- Polydopamine nanoparticles can be soluble in in acidic conditions (pH= 2-3).