you must see this paper from DiabetesCare (https://care.diabetesjournals.org/content/26/8/2442) to see its role on IR/IS. It is well known to be measured in human as a markers for metabolic syndromes but even though it could be interesting to use it to overcome such diseases, since adiponectin can have other roles in cells (as anti-inflammatory effects, reproduction changes, cancer onset...), lifetime changes should produce more risky results (nutrition, sports...) than use of hormones.