I want to do a structural comparison of yeast and human metallothionein using bioinformatics tools. Can anybody suggest a suitable tool?

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Tarana Arman

Thanks Qazi Mohammad. However, can you please comment on how much minimum similarity is required between the sequences to be used replaceably.

Serhii Vakal

I think sequence similarity is not the most important in this case. Given that the goal is to perform HPLC You should keep more attention to physicochemical similarity between these proteins, e.g. solubility, solvent accessible area, hydrophobicity etc.