I am working on the development of an elementary impurities method for an API by acid digestion via microwave and ICP-OES analysis. [API = Amiodarone HCl]
However, at the end of the microwave program, I notice that a platinum / black solid is impregnated in the Teflon tube. I figured it could be the iodine from API composition, that is not soluble in acid reagents.
Has anyone worked with the analysis of elemental impurities for a compound with a high concentration of iodine and can you help me with this? (microwave digestion)
Could the solid on the wall of the Teflon tube be the iodine?
Would add AgNO3 for precipitation work in this case?
Would it be correct to let the solid form on the tube wall and proceed with a simple filtration of the solution?
Yes, this substance can be iodum
An alkaline pH value is required for sample preparation of iodum impurities
I suggest you look up the archives of the Plasmachem-L ICP discussion board.
https://listserv.syr.edu/scripts/wa.exe?A0=PLASMACHEM-L
There is a search function that should help you out in the first instance, and you can always subscribe and post a question if that doesn't help.
There was a useful thread back in March 2020 about just such an issue.
In general, Iodine and nitric acid don't get on well. Digestions should be alkaline.
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