My drug is poorly soluble in DMSO. I tried 1%PEG4000 and it is dissolving, but i have doubt whether i can use it for IV. Because PEG4000 is a high molecular weight compond
Using PEG 4000 to dissolve your poorly soluble drug for intravenous (IV) administration raises safety concerns due to its high molecular weight and potential adverse effects. It's crucial to conduct biocompatibility studies and review the literature on PEG use in parenteral formulations before proceeding.
From what I know, PEG4000 is a high molecular weight compound, which might not be the best choice for intravenous use. It could cause issues like precipitation, immune reactions, or osmotic imbalances. However, if your drug dissolves in 1% PEG4000, you could try switching to a lower molecular weight PEG, such as PEG 400 or PEG 300, and see how that works. Alternatively, you could use a mixture of PEG 400 with ethanol or propylene glycol, which might help improve solubility. Hope this helps!
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