I am new to Nanoformulations. I have done the synthesis of NLC for an antifungal compound using the protocol published in Article Improved yeast delivery of fluconazole with a nanostructured...
At the end of the process, I got a mixture of milky white solution with solid coagulants. Is this a correct form of how NLC looks? I have also doubts about %w/w calculations. Kindly help me with the calculation
Dear Sathiyamoorthy,
According to my experience with NLCs, its final appearance depend on its composition, e.g. solid and liquid lipids, surfactants, etc.
My NLCs also get this "milky" appearance and I've noticed that It does not relate to particle's size and polydispersion index (PDI) by comparing to other NLCs with different composition. My colleagues recommend not to base on the final appearance of the formulation unless it is something very out of the ordinary (such as phase separation).
I don't know about the solid coagulants though...Maybe the components are not sufficiently miscible?
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