Jananishree Sathiyamoorthy

Micelles are needed to deliver a hydrophobic drug to an aquatic environment (human body). Otherwise, the hydrophobic drug will not be absorbed by the body. Polymers composed of alternating blocks of hydrophobic and hydrophilic monomers similar to surfactants form good micelles for the delivery of hydrophobic drugs.

Jananishree Sathiyamoorthy

Hydrophobic drugs have poor solubility in water, which can limit their bioavailability and therapeutic effectiveness. By incorporating hydrophobic drugs into a matrix of hydrophilic polymers, their dispersion and solubility can be improved, leading to better absorption and bioavailability in the body.

Dear Dr Jananishree

A combination of hydrophobic and hydrophilic polymers is often used for formulating hydrophobic drugs to improve their solubility, stability, bioavailability, and overall therapeutic efficacy. This approach is known as a "polymer blend" or "polymer matrix" strategy

reasons behind using this combination:

By combining hydrophobic and hydrophilic polymers, pharmaceutical scientists can optimize the formulation of hydrophobic drugs to achieve desired properties like solubility enhancement, stability, controlled release, and improved bioavailability. The specific selection of polymers and their ratios depends on the drug's characteristics, the intended route of administration, and the desired therapeutic outcomes.