As is stated in many reviews, the preinitiation complex could bind the 5' cap and 5' UTR in the mRNA and then scan the 1st AUG in downstream. After referring to several gene sequence, I've realized that there're also ATG in 5' UTR. Thus, I'm wondering how the preinitiation complex avoid treating the AUG in 5' UTR as the start codon.
It would be much appreciated if details can be provided as many as possible.
Thanks in advance!
Lech Kaczmarczyk
To serve as an efficient start, the AUG must be in a specific context, called Kozak sequence (named after the lady, who described it first). Certain genes have more than one efficient Kozak consensus site, leading to expression of different protein isoforms.
0 votes
0 thanks
- Badges
- Science topic
- Similar topics
- Biological Science
- Biochemistry
- Enzymology
- Enzymes
More Damon Feng Wang's questions See All
Similar questions and discussions