Does anyone know what drug or method is suitable to remove the sulfate group from an intramembrane enzyme? Note that my goal is to work in vivo and I do not want cytotoxicity.
Maryam Rahimi-Tesiye
Heparan N-sulfatase removes sulfate groups from the amino group of glucosamine residues present in HS. Structurally, this moiety is a sulphamate, distinct from sulfate, and therefore the enzyme is commonly referred to as sulphamidase.
Dear Kashif Ameer Do you think it is appropriate to use these enzymes to remove sulfate groups of an enzyme within the endoplasmic reticulum membrane? My goal is to inactivate the enzyme
Maryam Rahimi-Tesiye
I think you can use whereas, enzymes must not have synergy in terms of enzymatic activity
Kashif Ameer
Do you think it causes toxicity for the whole cell? Do you have another suggestion for inactivating the enzyme? I do not want to use the usual medicines.
Thank you very much for your response
- Badges
- Science topic
- Similar topics
- Biological Science
- Biochemistry
- Enzymology
- Enzymes