There are several methods to measure calcium oscillation in live cells using chemical or genetically encoded sensors.

To answer your question it would be good to know what kind of cells/tissue you want to use and which time scale you are interested in.

calcium imaging

Thanks. I am using RAW264.7 cell. I want to measure calcium oscillation in early time point (0~600 seconds). How I can do that easily? 

Can you do imaging? Fura-2 works perfectly in primary cultured heart cells. Fura-2 is a high affinity calcium indicator and measured at 2 different wavelength and the ratio will show the oscillations. An alternative are calcium sensors that you express in the cells.

Thanks a lot.

My sample also have some fluorescence we used to measure at 370/440nm. Will it interfere with calcium measurement by this method (Fura-2)? And for imaging, what equipment are  required? Thank you very much.

As for the equipment, you need to have access to an imaging microscope. You may need the appropriate filter to detect the oscillations with fura-2. In addition, the software you want to use should allow you to record relatively fast changes.

However, the excitation wavelengths for Fura-2  are 340 and 380 nm. So, if your sample contains already a fluorescence indicator that is measured at 370 nm, than Fura-2 is may not be a good choice. I have attached a chapter from the Molecular Probes handbook, which may suggest you a different dye to use.

Good luck!  

Thank you very much.