Hi Mahdi,

Are you going to prepare your chewable tablets using wet granulation or direct compaction?

I tried both of them with standard levels of sweetening agent i.e. Sucralose. But the bitter and sour tests were still possible while chewing.

also I tried wax dispersion method with no acceptable result.

Thamer Omar

In this case it is better to focus on wet granulation methos.Did you try Mannitol instead of Sucralose? How much the % of I-carnitine in the tablet? what is the size or weight of the tablet?@Mahdi Zeinali

Yes you're right, wet granulation seems more logical. I'm trying wet granulation methods.

I used Sucralose because it is at least 300 times sweeter than mannitol.

732.7 mg L-carnitine tartrate (=500 mg L-Carnitine) and other excipients are necessary that will increase the weight of tablet to about 1500-2000 mg (Oblong-22).

Thamer Omar

Ok.This makes sense.Try to add flavor (peppermint flavor for example)

Mahdi Zeinali