Please go through this article

https://doi.org/10.1080/14786419.2016.1258562

Thank you for your suggestion.

I guess a real (close to complete) separate isolation is tantamount to impossible,

if there is a need for both compounds in a reasonably pure state preparative HPLC is the way to as seen in the paper suggested by Mr. Chowdhury.

Check https://pubmed.ncbi.nlm.nih.gov/26255810/

https://pubmed.ncbi.nlm.nih.gov/20091132/

Also check https://www.sciencedirect.com/science/article/pii/S1319016420301535

https://labmonk.com/isolation-and-detection-of-active-principles-sennoside-from-senna

Also check on this paper

https://www.mdpi.com/1420-3049/27/1/298/pdf

Please check these.

https://www.sciencedirect.com/topics/medicine-and-dentistry/sennoside-b

https://www.sciencedirect.com/topics/medicine-and-dentistry/sennoside-a