I am studying the recombination of X chromosome using 16 STR markers. I have 77 pedigrees each consisting of 3 generations. I used Mendel 16 software to calculate LOD scores and recombination fractions. But Mendel 16 does not provide confidence intervals (CI) for these. Couple of research papers have mentioned they have calculated CI assuming Poisson distribution with the aid of CI calculators available on the web (http://statpages.org/confint.html). But it is not clear to me how to do this as that requires observed events. if observed events are the number of meiosis, then it would be same for each marker. so, confidence interval cannot vary between markers then. I would appreciate it very much if someone can help me to solve this.