Hello everyone!
I would very much appreciate any help with the following. I have some experimental compounds which have never been tried in animal studies before, and have no close analogues. The only usable information about them are their LD50s (for mice), and I need to calculate appropriate doses for an experiment in rats (we are to evaluate efficacy, not toxicity). What would be the best approach to converting an LD50 to a presumably therapeutic dose for animals? Any advice would be super helpful.
Thanks in advance!