Dear users,
I would like to use survival models to test differences in the total time (in days) for tissue regeneration from a specific type of wound.
In this case the event would be 0 (not fully regenerated) and 1 (fully regenerated). The problem is that I know the interval in which regeneration occurs, but in some situations I am sure that regeneration occurred much earlier than observed.
For example, if I check an individual 800 days after the wound was first observed, it will be fully regenerated but regeneration happened before day 800. However, (I think) survival models will consider that regeneration happened at day 800.
How should I proceed? In my case study, all individuals observed after 250 days had their wounds fully regenerated. I thought that maybe I could truncate days after 250, but there's no way I can tell for sure that all individuals were fully regenerated after that period, so probably this is not the most correct approach.
I also tried to use left censored intervals, where the lower limit would be 0 (the time at which wound is first observed) and the upper limit the time when regeneration is observed).
Any advice?
Thank you in advance
1)What is your criterium for full regeneration or what is the general accepted critrium (nice is criteria).
2) Whether you like or not, in regeneration research steps of checking should be as small as possible.
Thus recalculating via a model is a bad idea, unless you know the time behavior of the criteria.
Thank you for your comment... probably I should have given some more insights on my study.
Regarding your first question, I am working with bats, and one of the standard procedures for genetic sampling is to collect a piece of wing membrane and the membrane will regenerate after a certain time. This is what I am interested, check how long will it take to be fully regenerated. This leads me to another question, would it be possible to include different regeneration classes in a survival model?
As for the second, I am working with wildlife populations, so "research steps of checking" are totally dependent on whether an individuals is recaptured or not.
Thank you once again
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