How to biologically validate gene interaction for a particular disease?

05 May 2013 1 3K Report

Presently I am working on reconstruction of genetic regulatory network (GRN) from colon cancer gene expression data. I identified few deferentially expression genes (around 100) and using some techniques found regulatory relationship among these identified genes. Now I have to validate these inferred interaction with biological database for its correctness.

Kindly provide me some source databases, literature or tools to validate identified interactions in case of disease.

Eric Jakobsson

In addition to gene interaction networks databases (BioGrid, Kegg, String) you might want to try an ab initio tool for measuring similarity among promoter regions called D2Z. Contact Ruth Kantorovitz (Mathematics University of Illinois) for details if you wish to follow up.

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