Literature states that Ethanol imparts negative charge to ethosomes. any possible explanation how it gives negative charge to ethosomes as ethanol is neutral . In ethosomes we normally use 20-45% v/v ethanol. What is the charge of ethanol?
Dear Peram,
Ethanol is an organic solvent in the category of alcohols, ie organic compounds hydroxylated (OH group in their structures). Its carbonic chain CH3CH2OH is composed of an apolar (CH3CH2-) and a polar (-OH) part. Therefore, the ethanol molecule already has an inherent polarity due to this commented characteristic. When placed in water (solution, as indicated: 20-45% v / v) this polarity is amplified and may fragment the molecule into two new parts depending on the interaction with water. The fragmentation would be by acidity effect according to the equation: CH3CH2OH + H2O --- CH3CH2O- and H3O +. As the apolar part is negative (CH3CH2O-) and has affinity for the etosomes, hence the explanation for this charge.
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