Type 2 diabetes is known to be due to insulin resistance, dysfunctional insulin sensitivity and impaired insulin secretion. Induction of autophagy has been reported to ameliorate type 2 diabetes complications via TFEB, mTORC1, AMPK and other pathways. Late onset autophagy was also been reported to be detrimental rather than being beneficial. I did like to know how induction of autophagy affects insulin secretion especially as it affects the beta cell biology.
Sinan Ibaguner
As the word autophagy means eating itself which is an autoimmunity and of course affected beta cells will decrease in number and some in size and some will die (necrosis).
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