The active site is where the enzymatic reaction takes place: a place where the substrate binds and is converted to a product.

There are almost 200 experimental structures of the human epidermal growth factor receptor (UniProt: P00533), each with a reference to the primary publication with detailed description of the structure.

There are 23 amino acid residues missing in the 3W2S structure.

Hi Pranay Agarwal

its either you obtain the active site from the literature that comes with the PDB or from Uniprot or you can check the compound that comes with the PDB or from some online servers they will predict the active site for you.

after you determine the active site you just write the active site residues and open the pdPDBb in autodock tools open the grid map search for the residues that you have written them to try to cover them with the grid box then you will get the X, Y, Z.