I am trying to figure out from the literature that how different the cell lines developed from primary tumor tissue are than the circulating tumor cells (CTC) found in the blood of cancer patients.
Pan-cancer whole-genome analyses of metastatic solid tumours. This paper describes the mutational signatures of primary vs metastatic tumours, hence reflecting any changes that CTCs undergo in the blood.
Genomics alterations of metastatic and primary tissues across 15 cancer types. Herein, genomic changes are also evaluated.
CTCs need certain survival advantages to make it to a second organ, overcoming fluid forces, immune attacks, dependency on substrate etc. Whether surviving CTCs possess this ability prior to their entrance in blood or whether they acquire it in the blood, through interactions with blood cells (neutrophils, platelets) or even from the fluid flow, is up to debate. There have been controversies around but it seems that each concept comes with it's merits. If you read towards these directions, you will get an elaborate view on your question.
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