Prospective fate maps show that cells of different germ layers and different subdivisions within germ layers are partially segregated from one another in the epiblast and primitive streak. however , Gerhart et al (2007) demonstrate that the epiblast contains both multipotent cells and a subpopulation of cells that are stably committed to the skeletal muscle lineage before the onset of gastrulation .
Monte et al.[1983] suggest that pattern of metastatis in malignant melanoma may related to the embryological derivation of tissues involved.
could there is specific interaction between deifferent segregation in epiblast or they exposed to related factor that may explain organ - specific metastases ?
this make sense or there is something i understood wrongly ?
“Seed and Soil Theory” is well-known to understand the preferential distant organ/ tissue in which the particular kind of cancer cells forms the metastatic foci. Further, the genetic/epigenetic alteration during the embryonic development is responsible for aggressive cancer development. The tumor involved in skeletal muscle is frequently childhood-onset such as rhabdomyosarcoma etc, but the distant metastasis to the muscle is not common among several kinds of tumors for precisely unknown reason.
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