How can we find mechanism of drugs based on molecular docking, because there are no any freely available online docking softwares?? Can any one share?

More Muneer Ahmed Qazi's questions See All

Feeding zebrafish larvae properly, so how many grams or milligrams of Artemia should be given to 6 dpf larvae?

According to standard guidelines, experts suggest proper feeding ratios to grow the ZF healthly.

15 June 2024 4,354 1 View

On average, how many rounds of revision does a manuscript undergo before being accepted in an SSCI journal?

This research question seeks to determine the average number of revision rounds a manuscript typically undergoes before being accepted by an SSCI journal. Understanding this average can help...

18 May 2024 5,815 6 View

Hello, How to synthesize Bi2O3 from BiCl3 by cation exchange?

Hello, How to synthesize Bi2O3 from BiCl3 by cation exchange, Which solvent is more suitable for this cation exchange besides H2O and CH2OH?

14 April 2024 7,080 0 View

I want bird impact analysis on leading edge with different lattic structures as support structure.How to combine lattic structure with leading .?

I want bird impact analysis on leading edge with different lattic structures as support structure.How to combine lattic structure with leading edge in assemblt module ?

02 March 2024 5,527 0 View

I want to know about the interpretation of the data obtained through LC-MS (Agilant MassHunter Qualitative Analysis?

I have three native plant proteins. After digesting them, their peptides were analyzed through LCMS Agilant MassHunter qualitative analysis. I have no idea how to analyze the chromatogram peaks...

19 December 2023 1,262 4 View

What are the best programs for simulating solar cells?

PV Simulation

15 August 2023 1,165 0 View

Which type of data should I use? Either mean of variables of a factor or data from factor analysis . I have to perform t-test, mediation analysis ?

Hello I want to perform a t-test, mediation analysis (Process 4 Hayes), and moderation mediation analysis (Process 7 Hayes). Which type of data should I use? Either mean of variables of a factor...

23 January 2022 6,641 13 View

I am doing a meta analysis in which all the selected articles are single arm observational studies. So is there a need to do quality assessment?

I did try modified Newcastle Ottawa scale but after removing the comparability of cohorts options, I can score out of 6 only in which most articles are getting only 4 or 5 which is not considered...

10 September 2021 3,082 6 View

What is the relationship between Photosynthetic rate (Pn) and intracellular CO2 (Ci)?

What is the relationship between Photosynthetic rate (Pn) and intracellular CO2 (Ci)? How the Ci may affect the Pn, and whats their relationship, either positive, negative, or both are possible...

30 August 2021 8,732 5 View

LIMS software recommendations?

I am interested in a software/solution which will allow employees across the company to submit request for various analyses in the labs, allow the lab managers to track the samples and work load...

10 June 2021 10,043 4 View

GC-MS retention index prediticon?

Hello experts, Does anyone know any free software about retention index prediction ?

08 August 2024 7,403 2 View

Why does my protein refolded to beta sheet during thermal denaturation analysis?

Hi! So i attempted to understand a novel protein behavior towards heat application by analyzing its secondary structure change. I subjected the protein to a thermal denaturation analysis using...

06 August 2024 1,989 3 View

Are there instances where molecules with larger molecular weights exhibit greater mobility than those with smaller molecular weights?

Hi, I know that low molecular weight (MW) molecules generally tend to have higher mobility, while high molecular weight molecules tend to have lower mobility. However, in my experimental...

06 August 2024 1,495 2 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

How to start a Molecular Dynamics Simulation?

Is it possible to conduct a molecular dynamics simulation to see the effects of a specific carbohydrate on the structure of lipids (e.g., micelle structure)? I am a beginner in this field and plan...

03 August 2024 3,371 3 View

Which will be the best software for the Hydration shell analysis with molecular dynamics?

I am using a windows system, what software I should use for hydration shell analysis with molecular dynamics?

02 August 2024 3,143 4 View

Can anyone provide me with molecular docking softwares/ websites?

Molecular docking software/ websites?

02 August 2024 8,704 7 View

Transfection in HEK293T cells?

Dear All, I am trying to transfect a pCDNA3.1 vector containing my gene of interest. The purpose is to figure out the localization of the protein of interest. I have fused the protein with GFP on...

31 July 2024 9,892 4 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

How to retain the a GFP tagged gene expression in stable cell line?

Hello , I established a stable cell line expressing GFP tagged to a centrosomal gene having G418 drug selection marker. I validated the stable line by IFA and Western blotting, results are fine....

29 July 2024 5,007 0 View

Indu Kumari

There are online docking servers. Some of them are HEX, SwissDock, PATCHDOCK, HADDOCK, GrammX, Rosetta.

Muneer Ahmed Qazi

Thank you very much Indu and Himanshu... I'll follow the suggestions and will let u know about the outcomes... ! :-)

Somasekhar Tiruveedhula

Dear Muneer,

mcule also available freely for one week as guest because it is commercial one.It directly shows hits when ur interested molecule docked to particular protein.