https://www.researchgate.net/publication/267924449_RELEASE_AND_PERMEATION_KINETICS_OF_A_MODEL_ANTIBIOTIC_FROM_HPMC-CARBOPOL_BASED_BUCCOADHESIVE_MATRIX_TABLETS

Conference Paper RELEASE AND PERMEATION KINETICS OF A MODEL ANTIBIOTIC FROM H...

I cant find the full text.....

Kopcha kinetics

Qt = At1/2 + Bt

Kopcha kinetics model describes how to quanify contribution of diffusion & polymeric relaxation.(where A = diffusional constant and B = erosion constants) and Qt is the amount of drug dissolved in time t.,If you divide both side by t you will get                             Qt/t =A/t1/2+B.

 The above equation resembles Y=mx+C

By ploting Qt/t vs 1/t1/2, you will find slope means A ,  and intercept means B.

Thanks for your reply. Is there any limit for stating the contribution of polymeric relaxation and erosion? 

It will be great if you could provide the details of other model which I requested in my Q&A section. 

You know A = diffusional constant and B = erosion constants,

 To be diffusion dominated drug release  A must be much higher than B.

 Theoretically  A/B should be more than 1 for that purpose.

Sir please told me that how could I plotted this equation in exel sheet. If I plotted these equation in exel sheet I always found A value which is negative. How can I solve this problem?

B Value is nagative was appear. True