Tareq Abdhilkadhim Naser Alasadi

• Ozempic is a synthetic/artificial GLP-1 (Glucagon-Like Peptide-1) receptor agonist that increases glucose-dependent insulin secretion, decreases inappropriate glucagon secretion, slows gastric emptying; also acts in the areas of the brain involved in regulation of appetite and caloric intake[1] and clinically usually suppresses appetite. This last I feel (not proven though) is its main impact on diabetes. My most concerning reservations about its use is related to its half-life elimination: ~1 week. This is far beyond the natural bioavailability time of physiologically induced secretion GLP-1 from the intestine (enteroendocrine L cells) in response to a high concentration of glucose in the intestinal lumen[2]. I therefore anticipate negative feedback on natural secretion of GLP-1 and resultant deconditioning or loss of the enteroendocrine L cells (not proven to my knowledge, but logical). I would anticipate binge eating, loss of the other positive effects on insulin sensitivity, and fast gastric emptying during the recuperation time for GLP-1 natural secretion.
• What to do: Sorghum. I advise the following type of patients: 1. diabetic patients who need to decrease their glucose producing foods. 2. overweight patients. 3. acquired mitochondrial dysfunction disorders (for nutrition control).
• Why: the GLP-1 peaks 30 minutes after sorghum intake and lasts another 3.5 hours approximately. Naturally. It does suppress appetite and shows positive impact on other interactions between insulin and the incretin hormones, GLP-1 and GIP, as well as PYY[3] which should help in the battle against diabetes.

References:

• [1] UpToDate
• [2] Endocrine Pancreas | Endocrine Physiology, 6e | AccessMedicine | McGraw Hill Medical. (n.d.). Retrieved November 23, 2023, from https://accessmedicine-mhmedical-com.ccmain.ohionet.org/content.aspx?sectionid=275922312&bookid=3307#275922353
• [3] Stefoska-Needham, A., Beck, E. J., Johnson, S. K., Chu, J., & Tapsell, L. C. (2016). Flaked sorghum biscuits increase postprandial GLP-1 and GIP levels and extend subjective satiety in healthy subjects. Molecular Nutrition & Food Research, 60(5), 1118–1128. https://doi.org/10.1002/MNFR.201500672

Ozempic is a medication primarily used to treat type 2 diabetes, and it may contribute to weight loss as a side effect. To control your diet while using Ozempic and potentially enhance weight loss:Focus on a well-balanced diet with plenty of vegetables, lean proteins, whole grains, and limited amounts of processed foods and sugars.Portion control: Be mindful of portion sizes to avoid overeating. Consider using smaller plates to help control portions.Regular meals: Eat regular, balanced meals to help stabilize blood sugar levels. Avoid skipping meals, which can lead to overeating later.Stay hydrated: Drink plenty of water throughout the day. Sometimes, our bodies can mistake thirst for hunger.Monitor blood sugar levels: Regularly check your blood sugar levels as advised by your healthcare provider to ensure they are within the target range.Physical activity: Incorporate regular physical activity into your routine. This can complement the effects of Ozempic and contribute to weight loss.

"What are the possible side effects of Ozempic®?

Ozempic® may cause serious side effects, including:

• inflammation of your pancreas (pancreatitis). Stop using Ozempic® and call your health care provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
• changes in vision. Tell your health care provider if you have changes in vision during treatment with Ozempic®.
• low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Ozempic® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery.
• kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration.
• serious allergic reactions. Stop using Ozempic® and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat.
• gallbladder problems. Gallbladder problems have happened in some people who take Ozempic®. Tell your health care provider right away if you get symptoms which may include: pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools.

The most common side effects of Ozempic® may include nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation."

https://www.ozempic.com/how-to-take/side-effects.html