Clofazimine may be suitable for formulation with Lipodisq particles - a nano particle drug/cosmetic delivery system developed by Malvern Cosmeceutics Ltd (UK).
The Lipodisq technology allows a hydrophobic material to be formulated into a particle system that is then rendered water soluble - the hydrophobic materials are not exposed to the aqueous media. This allows for a stable aqueous solution of particles with a lipid/hrydrophobic core that will carry the hydrophobic drug/molecule/membrane protein of interest.