I need to synthesize alpha beta unsaturated isoleucine and valine. Can anyone tell me some easy synthetic strategy to do so, along with the reference for that method.
It will be directly change to the imine by mesomeric effect guided by the carboxylic group.
Then it will be easily attacked by water to produce alpha keto acid.
This means that you can obtain your compound if you undergo the reaction between an alpha keto acid with ammonia dissolved in THF (preferred) or absolute alcohol