Im searching to have it in a spherical way, orbeez-like.
the most general approach is to drop alginate solution to Ca 2 solution it worms spheres instantly. but it may be not stable too long at pH above 7
Dissolve sodium alginate in water and mix with crosslinkers like epichlorohydrin or acrylamide with initiators, then heat to form a covalently crosslinked hydrogel. Finally, immerse the hydrogel in a solution of divalent/trivalent cations (e.g., Ca²⁺) to ionically crosslink and strengthen the gel.
To obtain uniform alginate beads, the best method would be using microfluidics. Using pressure-driven flow control like a pressure controller for stable and accurate flow and a T-junction microfluidic chip to generate alginate droplet in oil.
you can find an explicative scheme on here : https://www.elveflow.com/microfluidics-application-packs/easy-microfluidic-alginate-beads-generation-pack/?utm_source=researchgate.com&utm_medium=social&utm_campaign=researchgate_alginatebeads
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