can anyone tell the the specific gene for oral cancer? in most of the oral cancerous conditions P53 were expressed. if i consider this gene as a specific gene means how can i justified?
p53 (i believe you are referring to p53 tumor suppressor gene) is a gene that often triggers apoptosis (programmed cell death) in cancerous cells. ~50% of cancerous growths have mutations that have occurred in the p53 region. Essentially a cancerous mutation will occur in a divided cell, then p53 will trigger cell death. However, if p53 mutates nothing (usually) happens. If that mutated cell then has a new cancerous mutation then the dysfunctional p53 gene now won't trigger cell-death and if other bodily defenses fail to kill the doubly-mutated cell then cancer will occur. I wouldn't say that p53 is specific to just oral cancer, as much as it's a very general anti-cancer gene that serves as a first line of defense.
p53 gene is the most commonly mutated tumor suppressor in human cancers. p53 is therefore not a specific gene for OSCC (or any other type of oral malignancy whatsoever).
"in most of the oral cancerous conditions P53 were expressed" http://www.ncbi.nlm.nih.gov/pubmed/24518701
http://www.ncbi.nlm.nih.gov/pubmed/10955828
Here's some evidence to the contrary. I therefore disagree with the statement although there is some evidence to back it up.
However, the oncogenic "version" of p53 has been characterized and the elevated expression of p53 is linked to premalignant change http://www.ncbi.nlm.nih.gov/pubmed/18223686 http://www.ncbi.nlm.nih.gov/pubmed/19192052
Hope these are of help.
I mean, I Wish there was one specific gene for oscc.....
Best Regards,
Aaro T.
Briefly, p53 is not specified to oral cancer because it can be found in many other types of cancer types. However, if you looking for a specific gene expression oral cancer, then you need to do comparative analysis between of gene expression profile between different types. In this case you may use " formal concept analysis", it will help you very much.
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