How can I find out the interaction of an osteoarthritis patient's DNA with Vitamin B complex?

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Panayot Tanchev

Why are you looking for interaction of DNA in osteoarthritic patients with vitamin B complex ? Do you have any hypothesis or idea ? I do not think you will find any relationship in the pertinent literature. The properties and functions of B vitamins are related to variable skin, neurologic and psychic disorders, and not to such affecting the musculo-skeletal system. A study on the suggested interaction seems to me to be of a "pure science" character.

Marco Chávez Cadena

There are some good studies than can give you ideas about where to look, I would start looking the combinations with Diclofenac the possible synergistic effects of Vitamin B complex an are not clear but the possible answer could be in some of these mechanism: increase in the availability of substances that Blockade nociceptive transmitters, also it have been reported a opioid mechanism and nitric oxide liberation and this have been probed to some degree with the inhibition of the analgesic effect of vitamin B complex trough the administration of naloxone an L-NAME.

Here are some works that will give you a good idea about where to look including one in osteoarthritis patients.

1. Magaña-Villa M, Rocha-González H, Fernández del Valle-Laisequilla C, Granados-Soto V, Rodríguez-Silverio J, Flores-Murrieta F, et al. B-vitamin Mixture Improves the Analgesic Effect of Diclofenac in Patients with Osteoarthritis: A Double Blind Study. Drug Research. 2013 Mar 22;63(06):289–92.

2. Dehghan M. Comparative Effectiveness of B and E Vitamins with Diclofenac in Reducing Pain Due to Osteoarthritis of the Knee. Medical Archives. 2015;69(2):103.