Hi, I am now working on establishing mouse model by Hepa1-6 cell line. 7 days after subcutaneously injection into male C57BL/6J mouse with 5*106 Hepa1-6 cells, solid tumor was established (~0.5cm). However, the tumor was cleared at day 14. I also did intrahepatic injection, no tumor was detected by in vivo image (with luciferase label). Do anyone knows how to establish in vivo model by the Hepa1-6 in C57BL/6J mouse (s.c or i.h)?Is there anything I have to pay special attention? I plan to test my potential anti tumor drug in the model.
Many many thanks.
Jingying
Hello
look at the links here , Hope help you
Good luck
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159281/
http://onlinelibrary.wiley.com/doi/10.1002/eji.201343794/pdf
http://jnci.oxfordjournals.org/content/104/23/1796.full.pdf
http://www.ncbi.nlm.nih.gov/pubmed/22967464
http://www.cjpp.net/EN/abstract/abstract10793.shtml
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