K1 and k2 are cardiac kinetic parameters which define wash-in and wash-out rate in a compartmental model of the cardiac muscle. j1 and j2 are two coefficients which are related to K1 and k2. using equation Count=-C1.exp(-j1.t)+C2.exp(-j2.t) time-acitivity curve for myocardium can be plotted which shows washin and washout rate of myocardium, but as far as I know K1 and k2 are somehow different from j1 and j2.
K1 and k2 are usually used with convolution = input function convolve with the TAC of the myocardium. The j1 and j2 on your equation will decribe only one TAC.
Etienne
Dear Etienne,
as far as I know in a one compartment model, input function must be convolved with K1.exp(-k2.t) which is transfer function of the model.
how many TACs are there in a one compartment model of myocardium? I think in this model there is just one TAC which can be described by the equation C1.exp(-j1.t)+C2.exp(-j2.t)
also,the shape of input function is the way that it can be plotted using this equation. so maybe to have myocardium TAC the equation C1.exp(-j1.t)+C2.exp(-j2.t) must be convolved with the transfer function.
I would be glad if you let me know what you think about it.
M.Reza
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