antibacterial activity has any relation with size and shape of silver nanoparticles? if shape is triangular then activity will increases compared to the spherical ? plz tell the size effect also?small size is good or big size nanoparticles?
Hi Sreelekha,
The antibacterial activity of silver stems from the release of silver ions. The specific application you have determines how fast and how much silver ions should be released to show the desired effect. The release can be modulated by selecting the size, shape, and surface coating of the added silver nanoparticles. For size the rule applies that the smaller the particles you choose, the bigger the surface area for release, thus faster release and higher dose (per unit of weight of added silver) but the duration will be shorter. So you can tune the release rate, released concentration and duration of release by using silver nanoparticles with different sizes.
The shape also matters as non-spherical silver nanoparticles (e.g. spheres, rods, or plates) will have different crystal facets which may dissolve at different rates, resulting in shape-specific silver release rates. So, also there you can tune release rate.
Finally if you need sustained release, you could encapsulate silver nanoparticles or given them a surface coating that modulates the release by providing a barrier towards release into the medium where the silver should act.
I hope this helps in gettign a first idea. There are lots of articles about release of silver ions from silver nanoparticles so I am sure you can find a good first estimate of what you would need for your application. Kind regards, Leo
Hello dear Sreelekha;
I read a very good interpretation of matter given by Leo Vleugels and I wanna suggest you to carefully read following published papers which are deal with the size and shape effect of antibacterial agents (metal oxide) on antimicrobial activity of them to accomplish your information and better and even better understanding of the reasons and applied mechanisms:
Article Influence of particle size on the antibacterial activity of zinc oxide
Article Does the Antibacterial Activity of Silver Nanoparticles Depe...
informative explanation?tnx for everyone. i sure read those articles
can i get Dr.Leo Vleugels more publications related to antibacterial activity...plz help me
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