How addition of Arg + Glu increase protein solubility?

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Dominique Liger

Hi there,

More precisely, Arg and glu as additives are preventing protein aggregation:

http://wolfson.huji.ac.il/purification/PDF/Literature/Golovanov2004.pdf

Akshay Pareek

I want to understand that is these single amino acids are able to interact with the folded amino acids .

The discussion of the paper I suggested for reading goes through this. Even though the mechanism s not clearly established...

Pratyush Kumar Das

One of the important paper in this direction is

http://pubs.acs.org/doi/pdfplus/10.1021/jp204462t

The proposed hypothesis in page no.11835 may address your query.