Most studies indicate that Trypanosoma brucei uses the host's T cells to find a way through to the brain, in particular to negotiate the laminin components of the basement membrane in the post capillary venule area. If this is the case then it would require a "synchronous swimming" traversal of the endothelial cell, that is to say a close and proximate association of the parasite and the lymphocyte. I was thinking that anti-lymphocyte serum might stop this eventuality, and was wondering if any body had tried it.
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