I am experiencing problem with single cell whole genome amplification from 10-12 cells only 3 or 4 amplifies and I have a smear on gel electrophoresis, Can anyone help me?
my experience of this is that the gels always look very smeared, often the data is good though. Best thing to do is sequence the DNA and look at the data quality. Are you doing WGS on the sample? what extraction method/ sequencing platform are you using?