How can nanotechnology-based drug delivery systems improve the therapeutic efficacy and reduce the side effects of conventional drugs?"
Hi !
There are many modulations that could be done to minimize toxicity like-Nanotechnology-based drug delivery systems enhance therapeutic efficacy by improving solubility, stability, and targeted accumulation of drugs, while reducing systemic toxicity through controlled biodistribution. For example, Doxil® (liposomal doxorubicin) encapsulates doxorubicin in PEGylated liposomes, limiting cardiac exposure and reducing cardiotoxicity. Abraxane® (albumin-bound paclitaxel) avoids Cremophor EL, thereby reducing hypersensitivity reactions and improving tumor uptake via albumin-mediated transport. AmBisome® (liposomal amphotericin B) localizes amphotericin B in liposomes, lowering free drug levels in plasma and reducing nephrotoxicity. Thus, nanocarriers minimize off-target interactions while maintaining therapeutic concentrations at diseased sites.
- Badges
- Science method